MULTIPLE VIRTUAL SCREENING APPROACHES FOR FINDING NEW HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE INHIBITORS: STRUCTURE-BASED SCREENS AND MOLECULAR DYNAMICS FOR THE PURSUE OF NEW POLY PHARMACOLOGICAL INHIBITORS

Abstract The RNA polymerase NS5B of Hepatitis C virus (HCV) is a well-characterised drug target with an active site and four allosteric binding sites.This work presents a workflow for virtual screening and its application to Drug Bank screening targeting the Hepatitis C Virus (HCV) RNA polymerase non-nucleoside binding sites.Potential polypharmacol

In the past decade, the emergence of chimeric antigen receptor (CAR) T-cell therapy has led to a cellular immunotherapy revolution against various cancers.Although CAR-T cell therapies have demonstrated remarkable efficacy for patients with certain B cell driven hematological malignancies, further studies are required to broaden the use of CAR-T ce

The Southern Ocean, a critical marine region on Earth, is undergoing significant environmental changes due to global climate change, including reductions in sea ice extent, ocean acidification, and alterations Granola in the Antarctic Circumpolar Current (ACC).The Cosmonaut Sea, notable for its dynamic sea ice and rich biological activity, remains

Along with the advances in technology, modern surveying technology developed rapidly, a series of high-tech equipments have been U-Desks invited and developed.A lot of cluster-based Remote Sensing image processing systems, at home or abroad, have been produced and used in production, such as PixelFactory, PixelGrid, CIPS etc.Been popularized and us

Since 2016, based on the regulation of 3ag/5ag Fuses the Minister of Energy and Mineral Resources number 12/2015, the government has enacted a policy of mixing biodiesel into diesel oil by 20 %, also known as B20.It is applied to all sectors that use diesel oil.In 2020, based on that regulation, Indonesia will continue to implement B30.Indonesia wi